Clinical Trials at CHI Health - CHI Health, Nebraska (NE) - Southwest Iowa (IA)
What is a Clinical Trial?

A clinical trial (also clinical research) is a research study in human volunteers to answer specific health questions. Carefully conducted clinical trials are the fastest and safest way to find treatments that are effective in human subjects.

Interventional trials determine whether experimental treatments or new ways of using known therapies are safe and effective under controlled environments. Observational trials address health issues in large groups of people or populations in natural settings.

Clinical trials are ongoing and some may not be listed. If you have any questions please email the CHI Health Research office or call 402-343-8511.

Condition Description Disease Site
LPS14587 (Ref number:199)

A randomized, controlled, parallel Group, 16-week open label study comparing the efficacy and safety of Toujeo [ Insulin glargine 300 units/ml] versus Lantus in subjects with type 1 diabetes mellitus.

Pancreas
AKEBIA (Ref number:195)

Protocol AKB-6548-CI-0014: Phase 3, Randomized, Open-Label, Active-Controlled Study Evaluating the Efficacy and Safety of Oral Vadadustat for the Correction of Anemia in Subjects with Non-Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) (PRO2TECT – CORRECTION) Protocol AKB-6548-CI-0015: Phase 3, Randomized, Open-Label, Active-Controlled Study Evaluating the Efficacy and Safety of Oral Vadadustat for the Maintenance Treatment of Anemia in Subjects with Non-Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) (PRO2TECT – CONVERSION)

REGENMED (Ref number:196)

Protocol AKB-6548-CI-0015: Phase 3, Randomized, Open-Label, Active-Controlled Study Evaluating the Efficacy and Safety of Oral Vadadustat for the Maintenance Treatment of Anemia in Subjects with Non-Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) (PRO2TECT – CONVERSION)

MK3475-164 (Ref number:201)

MK3475-164 A Phase II Study of Pembrolizumab in Previously Treated Subjects with Mismatched Repair Deficient or Microsatellite Instability-High Colorectal Carcinoma

Colorectal
Cardiac ABSORB (Ref number:181)

A Clinical Evaluation of Absorb™ BVS, the Everolimus Eluting Bioresorbable Vascular Scaffold in the Treatment of Subjects with de novo Native Coronary Artery Lesions

Heart
Cardiac Dal-GenE MHICC 2050 (Ref number:192)

Study Title:Double blind, randomized, placebo controlled, parallel group study to assess the effects of study drug on reducing the occurrence of major cardiovascular events in pts with acute coronary syndrome.A phase III, double-­-blind, randomized placebo-­-controlled study to evaluate the effects of dalcetrapib on cardiovascular CV) risk in a genetically defined population with a recent Acute Coronary Syndrome (ACS): The dal-­-GenE trial

Heart
Cardiac VICTORIA (Ref number:194)

A Randomized Parallel-Group, Placebo-Controlled, Double-Blind, Event-Driven, Multi- Center Pivotal Phase III Clinical Outcome Trial of Efficacy and Safety of the Oral sGC Stimulator Vericiguat in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF) - VerICiguaT Global Study in Subjects With Heart Failure With Reduced Ejection Fraction (VICTORIA). Site number 2526

Heart
Cardiac AEIOU (Ref number:191)

The AEIOU Trial: Apixaban in subjects undergoing planned radiofrequency catheter ablation of atrial fibrillation. Apixaban Evaluation of Interrupted Or Uninterrupted Anticoagulation for Ablation of Atrial Fibrillation

Heart
Cardiac IMPERIAL (Ref number:193)

Pre-market clinical study to asses Boston Sci drug-eluting stent in treatment of superficial femoral artery [SFA] atherosclerotic lesions.

Cardiac CIRT (Ref number:186)

A randomized, double-blind, placebo-controlled, event-driven trial of weekly low-dose methotrexate (LDM) in the prevention of cardiovascular events among stable coronary artery disease patients with type 2 diabetes or metabolic syndrome

Heart
Cardiac SILVER-AMI (Ref number:182)

Risk Stratification in Older Persons with Acute Myocardial Infarction: SILVER-AMI

Heart
Gastroenterology Gilead Hepatitis B ( HBV) (Ref number:189)

Obsevational, post marketing renalsafety surveillance registry in subjects with chronic hepatitis B ( HBV) infection with decompensated liver disease receiving nucleotide/side therapy.

Gastroenterology Humira Legacy (Ref number:175)

Registry looking for patients with moderate to severe active ulcerative colitis who receive Humira with or without immunomodulatory therapy.

Kidney DCI-CR845 (Ref number:198)

A PHASE 3 MULTICENTER, DOUBLE-BLIND, RANDOMIZED, PLACEBO-CONTROLLED STUDY TO EVALUATE THE SAFETY AND EFFICACY OF INTRAVENOUS CR845 IN HEMODIALYSIS PATIENTS WITH MODERATE-TO-SEVERE PRURITUS

Kidney SONAR (Ref number:197)

A Randomized, Mulitcenter, Double-Blind, Parallel, Placebo-Controlled study of the effects of study drug on renal outcomes in Type 2 Diabetic subjects with Nephropathy.

Nephrology FIGARO (Ref number:188)

A Randomized, Double-blind, placebo-controlled, parallel-group, multicenter, event driven Phase 3 study to investigate the efficacy and safety of finerenone on the reduction of cardiovascular morbidity and mortality in subjects with type 2 diabetes mellitis and the clinical diagnosis of diabetic kidney disease in addition to standard of care.

Nephrology ROXA (Ref number:176)

Randomized, double blind, placebo, controlled study evaluating the safety and efficacy of Roxadustat for treatment of Anemia in Chronic Kidney Disease patients not on dialysis.

Nephrology FIDELIO (Ref number:187)

A randomized, double-blind, placebo-controlled, parallel-group, multicenter, event-driven phase III study to investigate the efficacy and safety of finerenone, in addition to standard of care, on the progression of kidney disease in subjects with type 2 diabetes mellitus and the clinical diagnosis of diabetic kidney disase

Orthopedics Zimmer Metal on Metal Total Hip Replacement (Ref number:190)

Post market survellance study of Zimmer metal on metal hip

Type 2 Diabetes GSK Harmony (Ref number:184)

US post market requirement to evaluate the effect of albiglutide on cardovascular events in patients with Type 2 diabetes.

Ulcerative Colitis VARSITY (Ref number:200)

Study Title: VARSITY-A Randomized, Double-Blind, Double-Dummy, Multicenter, Active-Controlled Study to Evaluate the Efficacy and Safety of Vedolizumab IV Compared to Adalimumab in Subjects With Ulcerative Colitis.Efficacy and Safety of Vedolizumab IV Compared to Adalimumab in Subjects With Ulcerative Colitis. The enrollment goals for this study are 658 subjects (329 per treatment arm), from 09 July 2015 to 01 Oct 2016. Want 3 pts per site.