Salivary Gland Biopsy, Medical Tests, NE - CHI Health, Omaha
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Salivary gland biopsy
Salivary gland biopsy

Salivary gland biopsy


Salivary gland biopsy is the removal of cells or a piece of tissue from a salivary gland for exam.

Alternative Names:

Biopsy - salivary gland

How the Test is Performed:

You have several pairs of salivary glands that drain into your mouth:

  • A major pair in front of the ears (parotid glands)
  • Another major pair beneath your jaw (submandibular glands)
  • Two major pairs on the floor of the mouth (sublingual glands)
  • Hundreds to thousands of minor salivary glands in the lips, cheeks, and tongue

One type of salivary gland biopsy is a needle biopsy .

  • The skin or mucous membrane over the gland is cleaned with rubbing alcohol.
  • A local pain-killing medicine (anesthetic) may be injected, and a needle is inserted into the gland.
  • A piece of tissue or cells are removed and placed on slides.
  • The samples are sent to the lab to be examined.

A biopsy can also be done to:

  • Determine the type of tumor in a salivary gland lump.
  • Determine if the gland and tumor need to be removed.

An open surgical biopsy of the glands in the lips or the parotid gland can also be performed to diagnose diseases such as Sjogren syndrome .

How to Prepare for the Test:

There is no special preparation for a needle biopsy. However, you may be asked not to drink or eat anything for a few hours before the test.

For surgical removal of a tumor, preparation is the same as for any major surgery. You will not be able to eat anything for 6 to 8 hours before the surgery.

How the Test will Feel:

With a needle biopsy, you may feel some stinging or burning if a local numbing medicine is injected.

You may feel pressure or mild discomfort when the needle is inserted. This should only last for 1 or 2 minutes.

The area may feel tender or be bruised for a few days after the biopsy.

The biopsy for Sjogren syndrome requires an injection of the anesthetic in the lip or in the front of the ear. You will have stitches where the tissue sample was removed.

Why the Test is Performed:

This test is done to find the cause of abnormal lumps or growths of the salivary glands. It is also done to diagnose Sjogren syndrome.

Normal Results:

The salivary gland tissue is normal.

What Abnormal Results Mean:

Abnormal results may indicate:


Risks from this procedure include:

  • Allergic reaction to the anesthetic
  • Bleeding
  • Infection
  • Injury to the facial or trigeminal nerve (rare)
  • Numbness of the lip


Hsu AK. Indications, techniques, and complications of major salivary gland extirapation. Oral Maxillofac Surg Clin North Am. Aug 2009; 21(3):313-21. PMID: 19608047 .

Miller-Thomas M. Diagnostic imaging and fine-needle aspiration of the salivary glands. In: Flint PW, Haughey BH, Lund LJ, et al, eds. Cummings Otolaryngology: Head & Neck Surgery. 6th ed. Philadelphia, PA: Elsevier Mosby; 2015:chap 84.

Review Date: 2/9/2015
Reviewed By: Alan Lipkin, MD, otolaryngologist, private practice, Denver, CO. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.

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