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Arrhenoblastoma of ovary
See also: Sertoli-Leydig cell tumor
Stromal tumor; Gonadal stromal tumor; Sex cord tumor; Androblastoma
This is a rare tumor. It accounts for less than 0.5% of all ovarian tumors.
These tumors are found in women of all age groups, but are most common in young women.
This tumor releases male hormones, which cause the following symptoms in women:
- Deepening of the voice
- Increased acne
- Increased hair on the face and body
- Increased size of the clitoris
- Male pattern baldness
Exams and Tests
- Blood tests to check levels of hormones that may be released by the tumor
- CT scan of the pelvis and abdomen to see if the tumor has spread
- Ultrasound of the ovaries
Surgery to remove the tumor is the main treatment. If the cancer has spread, chemotherapy or radiation therapy may be considered.
The outcome of this disease depends on whether it has spread, and whether surgery can completely remove the tumor.
Arrhenoblastoma has a low chance of spreading. If the tumor is found early, the cure rate can be very good.
- Complications of surgery
- Masculine symptoms (virilization)
- Spread of the tumor if it is not completely removed
When to Contact a Medical Professional
Call your health care provider if you are a woman and have masculine symptoms, or you feel a lump in your lower belly area.
There is no good screening test. Regular gynecologic exams and recognizing masculine symptoms may help detect the disease.
Bulun SE, Adashi EY. The physiology and pathology of the female reproductive axis. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 17.
Coleman RL, Gershenson DM. Neoplastic diseases of the ovary: screening, benign and malignant epithelial and germ cell neoplasms, sex-cord stromal tumors. In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, eds. Comprehensive Gynecology. 5th ed. Philadelphia, PA: Mosby Elsevier; 2007:chap 33.
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.