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Corneal ulcers and infections
The cornea is the clear tissue at the front of the eye. A corneal ulcer is an open sore in the outer layer of the cornea. It is often caused by infection.
Bacterial keratitis; Fungal keratitis; Acanthamoeba keratitis; Herpes simplex keratitis
Corneal ulcers are most commonly caused by an infection with bacteria, viruses, fungi, or a parasite.
- Acanthamoeba keratitis occurs in contact lens users. It is more likely to happen in people who make their own homemade cleaning solutions.
- Fungal keratitis can occur after a corneal injury involving plant material. It may also occur in people with a suppressed immune system.
- Herpes simplex keratitis is a serious viral infection. It may cause repeated attacks that are triggered by stress, exposure to sunlight, or any condition that lowers the immune response.
Corneal ulcers or infections may also be caused by:
- Eyelids that do not close all the way, such as with Bell's palsy
- Foreign bodies in the eye
- Scratches (abrasions) on the eye surface
- Severely dry eyes
- Severe allergic eye disease
- Various inflammatory disorders
Wearing contact lenses, especially soft contacts that are left in overnight, may cause a corneal ulcer.
Symptoms of infection or ulcers of the cornea include:
Exams and Tests
Your health care provider will do the following tests:
- Exam of scrapings from the ulcer
- Fluorescein stain of the cornea
- Keratometry (measuring the curve of the cornea)
- Pupillary reflex response
- Refraction test
- Slit-lamp examination
- Tests for dry eye
- Visual acuity
Blood tests to check for inflammatory disorders may also be needed.
Treatment for corneal ulcers and infections depends on the cause. Treatment should be started as soon as possible to prevent scarring of the cornea.
If the exact cause is not known, you may be given antibiotic drops that work against many kinds of bacteria.
Once the exact cause is known, you may be given drops that treat bacteria, herpes, other viruses, or a fungus. Severe ulcers sometimes require a corneal transplant.
Corticosteroid eye drops may be used to reduce swelling and inflammation in certain conditions.
Your health care provider may also recommend that you:
- Avoid eye makeup
- Do not wear contact lenses at all, or do not wear them at night
- Take pain medications
- Wear an eye patch to keep out light and help with symptoms
- Wear protective glasses
Many people recover completely and have only a minor change in vision. However, a corneal ulcer or infection can cause long-term damage and affect vision.
Untreated corneal ulcers and infections may lead to:
- Loss of the eye (rare)
- Severe vision loss
- Scars on the cornea
When to Contact a Medical Professional
Call your health care provider if:
- You have symptoms of corneal ulcers or an infection
- You have been diagnosed with this condition and your symptoms become worse after treatment
Things you can do to prevent the condition include:
- Wash your hands well when handling your contact lenses.
- Avoid wearing contact lenses overnight.
- Get prompt treatment for an eye infection to prevent ulcers from forming.
Groos Jr. EB, Chang BH. Compliations of Contact Lenses. In: Tasman W, Jaeger EA, eds. Duane's Ophthalmology 2013 ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2013:vol 4; chap 27.
Keenan J, McLeod SD. Bacterial keratitis. In: Yanoff M, Duker JS, eds. Ophthalmology. 4th ed. St. Louis, MO: Elsevier Mosby; 2013:chap 4.12.
Keenan J, McLeod SD. Fungal keratitis. In: Yanoff M, Duker JS, eds. Ophthalmology. 4th ed. St. Louis, MO: Elsevier Mosby; 2013:chap 4.13.
Linn S, Bouchard CS. Noninfectious keratitis. In: Yanoff M, Duker JS, eds. Ophthalmology. 4th ed. St. Louis, MO: Elsevier Mosby; 2013:chap 4.17.
Soukiasian S. Peripheral ulcerative keratitis. In: Yanoff M, Duker JS, eds. Ophthalmology. 4th ed. St. Louis, MO: Elsevier Mosby; 2013:chap 4.16.
Tuli SS, Kubal AA. Herpes simplex keratitis. In: Yanoff M, Duker JS, eds. Ophthalmology. 4th ed. St. Louis, MO: Elsevier Mosby; 2013:chap 4.15.
Yanoff M, Cameron D. Diseases of the visual system. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Elsevier Saunders; 2011:chap 431.
Reviewed By: Franklin W. Lusby, MD, ophthalmologist, Lusby Vision Institute, La Jolla, CA. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.