In a person with Alzheimer disease, neurofibrillary tangles and plaques develop causing both structural and chemical problems in the brain. Alzheimer disease appears to disconnect areas of the brain that normally work together.
Review Date: 11/5/2014 Reviewed By: Joseph V. Campellone, M.D., Division of Neurology, Cooper University Hospital, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.